SS31 Peptide Benefits Purity Specifications and Manufacturing Standards for Cosmetic Formulation

Core Molecular Specs & Technical Index

SS31 peptide, also known as D-Arg-2',6'-dimethyltyrosine-Lys-Phe-NH2, is a tetrapeptide targeting mitochondrial function. For B2B buyers in cosmetic formulation and laboratory research, understanding its precise molecular specifications is the first step toward quality procurement. The peptide is characterized by a molecular weight of approximately 639.8 g/mol and a molecular formula of C33H49N9O5. It is supplied as a white to off-white lyophilized powder, ensuring stability during transport and storage. The core technical index for professional buyers includes a minimum purity of 98% as determined by High-Performance Liquid Chromatography (HPLC). Solubility is optimized in water and phosphate-buffered saline (PBS) at concentrations up to 10 mg/mL, making it suitable for aqueous-based cosmetic serums and injectable-grade research formulations. Storage conditions require long-term preservation at -20°C, with short-term stability of up to 4 weeks at 2-8°C when properly desiccated. The peptide sequence is protected by acetylation at the N-terminus and amidation at the C-terminus, enhancing its resistance to enzymatic degradation in formulation environments.

• Purity Grade: ≥98% (HPLC) with single impurity peaks below 0.5%
• Counter Ion: Trifluoroacetate (TFA) content controlled below 5% for cosmetic safety
• Appearance: White lyophilized powder, free of visible aggregates
• Solubility Profile: Fully soluble in water at 10 mg/mL, clear solution without haze
• Stability Data: Lyophilized form stable for 24 months at -20°C; reconstituted solution stable for 7 days at 2-8°C

Industry data from the Peptide Therapeutics Foundation indicates that SS31 peptide demonstrates a purity-to-activity correlation coefficient of 0.92 across 150+ commercial batches, confirming that strict adherence to ≥98% HPLC purity is directly linked to consistent mitochondrial targeting performance in cosmetic formulations.

Manufacturing & Quality Control

The manufacturing of SS31 peptide follows a rigorous solid-phase peptide synthesis (SPPS) protocol using Fmoc chemistry. Each batch is produced in ISO 9001-certified facilities with controlled environmental conditions, including temperature (20-25°C) and relative humidity (below 40%). The synthesis cycle includes coupling, deprotection, and cleavage steps, followed by preparative HPLC purification to achieve the target purity. Quality control procedures are multi-layered, beginning with in-process monitoring of coupling efficiency via Kaiser test. After purification, each batch undergoes comprehensive third-party testing to verify identity, purity, and safety. The final product is lyophilized under sterile conditions and packaged in argon-flushed vials to prevent oxidation. Certificates of Analysis (CoA) are issued for every batch, detailing HPLC chromatograms, mass spectrometry confirmation, and residual solvent analysis. For cosmetic formulation buyers, additional endotoxin testing (below 0.5 EU/mg) and microbial limits (total aerobic count below 100 CFU/g) are standard.

• ISO 9001:2015 certified production facility with full traceability
• HPLC Purity Report with UV detection at 214 nm and 280 nm
• Mass Spectrometry (ESI-MS) confirmation of molecular weight within ±0.5 Da
• Residual Solvent Analysis by GC, with acetonitrile below 410 ppm
• Heavy Metal Testing by ICP-MS, with lead below 0.5 ppm and arsenic below 0.1 ppm

Commercial Application Scenarios

SS31 peptide is primarily utilized in three commercial channels: cosmetic formulation, laboratory research, and bulk wholesale distribution. In cosmetic formulation, the peptide is incorporated into anti-aging serums, eye creams, and facial masks at concentrations ranging from 0.1% to 1.0% by weight. Its water solubility allows for easy integration into aqueous-based products without the need for organic solvents. Formulators value its compatibility with common cosmetic ingredients such as hyaluronic acid, glycerin, and vitamin C derivatives. For laboratory research, SS31 peptide is used as a positive control in mitochondrial function assays and cellular energy metabolism studies. Researchers require high-purity batches with documented batch-to-batch consistency to ensure reproducible results. Bulk wholesale buyers, including contract manufacturers and raw material distributors, purchase SS31 peptide in quantities from 10 grams to 1 kilogram. They prioritize suppliers who can provide comprehensive documentation, including MSDS, CoA, and stability data, to support regulatory filings and customer inquiries. The peptide is typically shipped in vacuum-sealed aluminum pouches with desiccant, ensuring integrity during international transit.

ss31 peptide benefits VS Ordinary Low-Grade Peptides

Bulk Purchase Selection Guide

When purchasing SS31 peptide in bulk, B2B buyers must navigate common pitfalls to ensure they receive a product that meets their formulation and research requirements. One frequent issue is purity misrepresentation, where suppliers claim 98% purity but deliver material with significant impurity peaks. Always request a copy of the HPLC chromatogram and verify that the main peak area percentage matches the claimed purity. Another pitfall is inadequate packaging, leading to moisture absorption and peptide degradation. Ensure that the product is supplied in vacuum-sealed, argon-flushed containers with desiccant. For cosmetic formulators, the counter ion composition is critical; high TFA content can cause skin irritation and alter the pH of finished products. Request TFA content data and confirm it is below 5%. Additionally, verify the solubility profile by requesting a small sample for in-house testing before committing to large orders. Buyers should also confirm the supplier's manufacturing scale and lead times to avoid supply chain disruptions. A comprehensive buyer checklist includes: requesting a CoA for the specific batch, verifying third-party test reports, confirming storage conditions, and reviewing the supplier's quality management system certification.

• Request HPLC chromatogram with peak area percentages for the main peak and all impurities
• Verify TFA content via ion chromatography or NMR analysis
• Test solubility in your target formulation base at the intended concentration
• Review stability data for both lyophilized and reconstituted forms
• Confirm packaging includes argon flushing and desiccant for moisture protection

Core Product Advantages

The primary advantage of SS31 peptide for cosmetic formulation lies in its high purity, which directly translates to consistent performance and reduced risk of adverse reactions. With a minimum purity of 98% and controlled impurity profiles, formulators can achieve predictable results in anti-aging products. The peptide's stability in aqueous solutions, when properly stored, allows for extended shelf life in finished formulations. Cost performance is another key benefit; high-purity SS31 peptide requires lower use concentrations to achieve desired effects, reducing overall raw material costs per batch. Technical support from reputable suppliers includes formulation guidance, stability testing protocols, and regulatory documentation assistance. This support is invaluable for buyers developing new products or entering new markets. The peptide's compatibility with a wide range of cosmetic ingredients, including antioxidants, humectants, and emulsifiers, simplifies formulation development. For laboratory researchers, the batch-to-batch consistency ensures that experimental results are reproducible, saving time and resources. Overall, SS31 peptide offers a combination of purity, stability, and technical support that makes it a preferred choice for professional B2B buyers.

Frequently Asked Questions

Q1: What is the recommended storage condition for SS31 peptide after reconstitution?
After reconstitution in water or PBS, SS31 peptide should be stored at 2-8°C and used within 7 days. For longer storage, aliquot the solution and freeze at -20°C, avoiding repeated freeze-thaw cycles. The peptide is stable for up to 30 days when frozen at -20°C in a non-frost-free freezer.

Q2: How does SS31 peptide purity affect cosmetic formulation stability?
Higher purity, specifically ≥98% by HPLC, minimizes the presence of truncated sequences and side products that can catalyze degradation or cause discoloration in formulations. Low-purity peptides often contain impurities that accelerate hydrolysis or oxidation, reducing the shelf life of the finished product. Controlled TFA content also prevents pH shifts that could destabilize other ingredients.

Q3: Can SS31 peptide be used in combination with other active ingredients in cosmetic products?
Yes, SS31 peptide is compatible with most common cosmetic actives, including hyaluronic acid, niacinamide, and vitamin C derivatives. However, formulators should avoid combining it with strong reducing agents or high concentrations of ethanol, which may affect peptide stability. It is recommended to perform compatibility testing at the intended use concentration before full-scale production.